Microduplications of 16p11.2 are associated with schizophrenia

Shane E. McCarthy; Vladimir Makarov; George Kirov; Anjene M. Addington; Jon McClellan; Seungtai Yoon; Diana O. Perkins; Diane E. Dickel; Mary Kusenda; Olga Krastoshevsky; Verena Krause; Ravinesh A. Kumar; Detelina Valentinova Grozeva; Dheeraj Malhotra; Tom Walsh; Elaine H. Zackai; Paige Kaplan; Jaya Ganesh; Ian D. Krantz; Nancy B. Spinner; Patricia Roccanova; Abhishek Bhandari; Kevin Pavon; B. Lakshmi; B. Lakshmi; Anthony Leotta; Jude Kendall; Yoon-ha Lee; Vladimir Vacic; Sydney Gary; Lilia M. Iakoucheva; Timothy J. Crow; Susan L. Christian; Jeffrey A. Lieberman; T. Scott Stroup; Terho Lehtimäki; Kaija Puura; Chad Haldeman-Englert; Justin Pearl; Meredith Goodell; Virginia L. Willour; Pamela DeRosse; Jo Steele; Layla Kassem; Jessica Wolff; Nisha Chitkara; Francis J. McMahon; Anil K. Malhotra

doi:10.1038/ng.474

Microduplications of 16p11.2 are associated with schizophrenia

Shane E. McCarthy
, Vladimir Makarov
, George Kirov
, Anjene M. Addington
, Jon McClellan
, Seungtai Yoon
, Diana O. Perkins
, Diane E. Dickel
, Mary Kusenda
, Olga Krastoshevsky
, Verena Krause
, Ravinesh A. Kumar
, Detelina Valentinova Grozeva
, Dheeraj Malhotra
, Tom Walsh
, Elaine H. Zackai
, Paige Kaplan
, Jaya Ganesh
, Ian D. Krantz
, Nancy B. Spinner

Patricia Roccanova, Abhishek Bhandari, Kevin Pavon, B. Lakshmi, B. Lakshmi, Anthony Leotta, Jude Kendall, Yoon-ha Lee, Vladimir Vacic, Sydney Gary, Lilia M. Iakoucheva, Timothy J. Crow, Susan L. Christian, Jeffrey A. Lieberman, T. Scott Stroup, Terho Lehtimäki, Kaija Puura, Chad Haldeman-Englert, Justin Pearl, Meredith Goodell, Virginia L. Willour, Pamela DeRosse, Jo Steele, Layla Kassem, Jessica Wolff, Nisha Chitkara, Francis J. McMahon, Anil K. Malhotra

Biology, Chemistry, Environmental Studies

Cold Spring Harbor Laboratory
Medical Research Council
National Institutes of Health
University of Washington
University of North Carolina at Chapel Hill
Harvard University
University of Chicago
University of Pennsylvania
Ontario Institute for Cancer Research
Rockefeller University
Warneford Hospital
Columbia University
Johns Hopkins University

Research & Scholarship: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1223-1227
Number of pages	5
Journal	Nature Genetics
Volume	41
Issue number	11
DOIs	https://doi.org/10.1038/ng.474
State	Published - Nov 2009

ASJC Scopus Subject Areas

Genetics

Access to Document

10.1038/ng.474

Cite this

McCarthy, S. E., Makarov, V., Kirov, G., Addington, A. M., McClellan, J., Yoon, S., Perkins, D. O., Dickel, D. E., Kusenda, M., Krastoshevsky, O., Krause, V., Kumar, R. A., Grozeva, D. V., Malhotra, D., Walsh, T., Zackai, E. H., Kaplan, P., Ganesh, J., Krantz, I. D., ... Malhotra, A. K. (2009). Microduplications of 16p11.2 are associated with schizophrenia. Nature Genetics, 41(11), 1223-1227. https://doi.org/10.1038/ng.474

McCarthy, SE, Makarov, V, Kirov, G, Addington, AM, McClellan, J, Yoon, S, Perkins, DO, Dickel, DE, Kusenda, M, Krastoshevsky, O, Krause, V, Kumar, RA, Grozeva, DV, Malhotra, D, Walsh, T, Zackai, EH, Kaplan, P, Ganesh, J, Krantz, ID, Spinner, NB, Roccanova, P, Bhandari, A, Pavon, K, Lakshmi, B, Lakshmi, B, Leotta, A, Kendall, J, Lee, Y, Vacic, V, Gary, S, Iakoucheva, LM, Crow, TJ, Christian, SL, Lieberman, JA, Stroup, TS, Lehtimäki, T, Puura, K, Haldeman-Englert, C, Pearl, J, Goodell, M, Willour, VL, DeRosse, P, Steele, J, Kassem, L, Wolff, J, Chitkara, N, McMahon, FJ & Malhotra, AK 2009, 'Microduplications of 16p11.2 are associated with schizophrenia', Nature Genetics, vol. 41, no. 11, pp. 1223-1227. https://doi.org/10.1038/ng.474

@article{de1086c56d2e4b91b91b05472f230a8d,

title = "Microduplications of 16p11.2 are associated with schizophrenia",

author = "McCarthy, \{Shane E.\} and Vladimir Makarov and George Kirov and Addington, \{Anjene M.\} and Jon McClellan and Seungtai Yoon and Perkins, \{Diana O.\} and Dickel, \{Diane E.\} and Mary Kusenda and Olga Krastoshevsky and Verena Krause and Kumar, \{Ravinesh A.\} and Grozeva, \{Detelina Valentinova\} and Dheeraj Malhotra and Tom Walsh and Zackai, \{Elaine H.\} and Paige Kaplan and Jaya Ganesh and Krantz, \{Ian D.\} and Spinner, \{Nancy B.\} and Patricia Roccanova and Abhishek Bhandari and Kevin Pavon and B. Lakshmi and B. Lakshmi and Anthony Leotta and Jude Kendall and Yoon-ha Lee and Vladimir Vacic and Sydney Gary and Iakoucheva, \{Lilia M.\} and Crow, \{Timothy J.\} and Christian, \{Susan L.\} and Lieberman, \{Jeffrey A.\} and Stroup, \{T. Scott\} and Terho Lehtim{\"a}ki and Kaija Puura and Chad Haldeman-Englert and Justin Pearl and Meredith Goodell and Willour, \{Virginia L.\} and Pamela DeRosse and Jo Steele and Layla Kassem and Jessica Wolff and Nisha Chitkara and McMahon, \{Francis J.\} and Malhotra, \{Anil K.\}",

note = "Jonathan Sebat and colleagues report the association of microduplication on chromosome 16p11.2 with schizophrenia, while the reciprocal microdeletion was associated with autism and developmental disorders. Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders1,2,3.",

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T1 - Microduplications of 16p11.2 are associated with schizophrenia

AU - McCarthy, Shane E.

AU - Makarov, Vladimir

AU - Kirov, George

AU - Addington, Anjene M.

AU - McClellan, Jon

AU - Yoon, Seungtai

AU - Perkins, Diana O.

AU - Dickel, Diane E.

AU - Kusenda, Mary

AU - Krastoshevsky, Olga

AU - Krause, Verena

AU - Kumar, Ravinesh A.

AU - Grozeva, Detelina Valentinova

AU - Malhotra, Dheeraj

AU - Walsh, Tom

AU - Zackai, Elaine H.

AU - Kaplan, Paige

AU - Ganesh, Jaya

AU - Krantz, Ian D.

AU - Spinner, Nancy B.

AU - Roccanova, Patricia

AU - Bhandari, Abhishek

AU - Pavon, Kevin

AU - Lakshmi, B.

AU - Leotta, Anthony

AU - Kendall, Jude

AU - Lee, Yoon-ha

AU - Vacic, Vladimir

AU - Gary, Sydney

AU - Iakoucheva, Lilia M.

AU - Crow, Timothy J.

AU - Christian, Susan L.

AU - Lieberman, Jeffrey A.

AU - Stroup, T. Scott

AU - Lehtimäki, Terho

AU - Puura, Kaija

AU - Haldeman-Englert, Chad

AU - Pearl, Justin

AU - Goodell, Meredith

AU - Willour, Virginia L.

AU - DeRosse, Pamela

AU - Steele, Jo

AU - Kassem, Layla

AU - Wolff, Jessica

AU - Chitkara, Nisha

AU - McMahon, Francis J.

AU - Malhotra, Anil K.

N1 - Jonathan Sebat and colleagues report the association of microduplication on chromosome 16p11.2 with schizophrenia, while the reciprocal microdeletion was associated with autism and developmental disorders. Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders1,2,3.

PY - 2009/11

Y1 - 2009/11

U2 - 10.1038/ng.474

DO - 10.1038/ng.474

M3 - Article

SN - 1061-4036

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