Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

Tom Walsh; Jon M. McClellan; Shane E. McCarthy; Anjené M. Addington; Sarah B. Pierce; Greg M. Cooper; Alex S. Nord; Mary Kusenda; Dheeraj Malhotra; Abhishek Bhandari; Sunday M. Stray; Caitlin F. Rippey; Patricia Roccanova; Vlad Makarov; B. Lakshmi; Robert L. Findling; Linmarie Sikich; Thomas Stromberg; Barry Merriman; Nitin Gogtay; Philip Butler; Kristen Eckstrand; Laila Noory; Peter Gochman; Robert Long; Zugen Chen; Sean Davis; Carl Baker; Evan E. Eichler; Paul S. Meltzer; Stanley F. Nelson; Andrew B. Singleton; Ming K. Lee; Judith L. Rapoport; Mary Claire King; Jonathan Sebat

doi:10.1126/science.1155174

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

Tom Walsh
, Jon M. McClellan
, Shane E. McCarthy
, Anjené M. Addington
, Sarah B. Pierce
, Greg M. Cooper
, Alex S. Nord
, Mary Kusenda
, Dheeraj Malhotra
, Abhishek Bhandari
, Sunday M. Stray
, Caitlin F. Rippey
, Patricia Roccanova
, Vlad Makarov
, B. Lakshmi
, Robert L. Findling
, Linmarie Sikich
, Thomas Stromberg
, Barry Merriman
, Nitin Gogtay

Philip Butler, Kristen Eckstrand, Laila Noory, Peter Gochman, Robert Long, Zugen Chen, Sean Davis, Carl Baker, Evan E. Eichler, Paul S. Meltzer, Stanley F. Nelson, Andrew B. Singleton, Ming K. Lee, Judith L. Rapoport, Mary Claire King, Jonathan Sebat

Biology, Chemistry, Environmental Studies

University of Washington
Cold Spring Harbor Laboratory
National Institutes of Health
Stony Brook University
Case Western Reserve University
University of North Carolina at Chapel Hill
University of California, Los Angeles

Research & Scholarship: Contribution to journal › Article › peer-review

Original language	American English
Journal	Science
Volume	320
DOIs	https://doi.org/10.1126/science.1155174
State	Published - Apr 25 2008

Disciplines

Biology
Bioinformatics
Genetics

Access to Document

10.1126/science.1155174

Cite this

Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., Stray, S. M., Rippey, C. F., Roccanova, P., Makarov, V., Lakshmi, B., Findling, R. L., Sikich, L., Stromberg, T., Merriman, B., ... Sebat, J. (2008). Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia. Science, 320. https://doi.org/10.1126/science.1155174

Walsh, T, McClellan, JM, McCarthy, SE, Addington, AM, Pierce, SB, Cooper, GM, Nord, AS, Kusenda, M, Malhotra, D, Bhandari, A, Stray, SM, Rippey, CF, Roccanova, P, Makarov, V, Lakshmi, B, Findling, RL, Sikich, L, Stromberg, T, Merriman, B, Gogtay, N, Butler, P, Eckstrand, K, Noory, L, Gochman, P, Long, R, Chen, Z, Davis, S, Baker, C, Eichler, EE, Meltzer, PS, Nelson, SF, Singleton, AB, Lee, MK, Rapoport, JL, King, MC & Sebat, J 2008, 'Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia', Science, vol. 320. https://doi.org/10.1126/science.1155174

@article{fcc08e39980547eca30cd1658b51ef22,

title = "Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia",

author = "Tom Walsh and McClellan, \{Jon M.\} and McCarthy, \{Shane E.\} and Addington, \{Anjen{\'e} M.\} and Pierce, \{Sarah B.\} and Cooper, \{Greg M.\} and Nord, \{Alex S.\} and Mary Kusenda and Dheeraj Malhotra and Abhishek Bhandari and Stray, \{Sunday M.\} and Rippey, \{Caitlin F.\} and Patricia Roccanova and Vlad Makarov and B. Lakshmi and Findling, \{Robert L.\} and Linmarie Sikich and Thomas Stromberg and Barry Merriman and Nitin Gogtay and Philip Butler and Kristen Eckstrand and Laila Noory and Peter Gochman and Robert Long and Zugen Chen and Sean Davis and Carl Baker and Eichler, \{Evan E.\} and Meltzer, \{Paul S.\} and Nelson, \{Stanley F.\} and Singleton, \{Andrew B.\} and Lee, \{Ming K.\} and Rapoport, \{Judith L.\} and King, \{Mary Claire\} and Jonathan Sebat",

note = "Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. We hypothesize that individually rare structural variants contribute to the illness. Microdeletions and microduplications 100 kilobases were identified by microarray comparative genomic hybridization of genomic DNA from 150 individuals with schizophrenia and 268 ancestry-matched controls.",

year = "2008",

month = apr,

day = "25",

doi = "10.1126/science.1155174",

language = "American English",

volume = "320",

journal = "Science",

publisher = "American Association for the Advancement of Science (AAAS)",

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TY - JOUR

T1 - Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

AU - Walsh, Tom

AU - McClellan, Jon M.

AU - McCarthy, Shane E.

AU - Addington, Anjené M.

AU - Pierce, Sarah B.

AU - Cooper, Greg M.

AU - Nord, Alex S.

AU - Kusenda, Mary

AU - Malhotra, Dheeraj

AU - Bhandari, Abhishek

AU - Stray, Sunday M.

AU - Rippey, Caitlin F.

AU - Roccanova, Patricia

AU - Makarov, Vlad

AU - Lakshmi, B.

AU - Findling, Robert L.

AU - Sikich, Linmarie

AU - Stromberg, Thomas

AU - Merriman, Barry

AU - Gogtay, Nitin

AU - Butler, Philip

AU - Eckstrand, Kristen

AU - Noory, Laila

AU - Gochman, Peter

AU - Long, Robert

AU - Chen, Zugen

AU - Davis, Sean

AU - Baker, Carl

AU - Eichler, Evan E.

AU - Meltzer, Paul S.

AU - Nelson, Stanley F.

AU - Singleton, Andrew B.

AU - Lee, Ming K.

AU - Rapoport, Judith L.

AU - King, Mary Claire

AU - Sebat, Jonathan

N1 - Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. We hypothesize that individually rare structural variants contribute to the illness. Microdeletions and microduplications 100 kilobases were identified by microarray comparative genomic hybridization of genomic DNA from 150 individuals with schizophrenia and 268 ancestry-matched controls.

PY - 2008/4/25

Y1 - 2008/4/25

U2 - 10.1126/science.1155174

DO - 10.1126/science.1155174

M3 - Article

VL - 320

JO - Science

JF - Science

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