The risk for persistent adult alcohol and nicotine dependence: the role of childhood maltreatment

Jennifer C Elliott; Malka Stohl; Melanie M. Wall; Katherine M Keyes; Renee D Goodwin; Andrew E. Skodol; Robert F Krueger; Bridget F. Grant; Deborah S Hasin

doi:10.1111/add.12477

The risk for persistent adult alcohol and nicotine dependence: the role of childhood maltreatment

Jennifer C Elliott
, Malka Stohl
, Melanie M. Wall
, Katherine M Keyes
, Renee D Goodwin
, Andrew E. Skodol
, Robert F Krueger
, Bridget F. Grant
, Deborah S Hasin

Psychology

New York State Psychiatric Insitute
Columbia University
National Institute on Alcohol Abuse and Alcoholism

Research & Scholarship: Contribution to journal › Article › peer-review

Abstract

 Background and aims: Alcohol and nicotine dependence are associated with considerable morbidity and mortality, especially when cases are persistent. The risk for alcohol and nicotine dependence is increased by childhood maltreatment. However, the influence of childhood maltreatment on dependence course is unknown, and is evaluated in the current study.
 
 Design: Physical, sexual and emotional abuse, and physical and emotional neglect, were evaluated as predictors of persistent alcohol and nicotine dependence over 3 years of follow-up, with and without control for other childhood adversities.
 
 Setting: National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).
 
 Participants: NESARC participants completing baseline and follow-up who met criteria at baseline for past-year alcohol dependence (n = 1172) and nicotine dependence (n = 4017).
 
 Measurements: Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS) measures of alcohol/nicotine dependence, childhood maltreatment and other adverse childhood experiences (e.g. parental divorce).
 
 Findings: Controlling for demographics only, physical, sexual and emotional abuse and physical neglect predicted 3-year persistence of alcohol dependence [adjusted odds ratio (AOR) = 1.50-2.99; 95% CI = 1.04-4.68] and nicotine dependence (AOR = 1.37-1.74; 95% CI = 1.13-2.11). With other childhood adversities also controlled, maltreatment types remained predictive for alcohol persistence (AOR = 1.53-3.02; 95% CI = 1.07-4.71) and nicotine persistence (AOR = 1.35-1.72; 95% CI = 1.11-2.09). Further, a greater number of maltreatment types incrementally influenced persistence risk (AOR = 1.19-1.36; 95% CI = 1.11-1.56).
 
 Conclusions: A history of childhood maltreatment predicts persistent adult alcohol and nicotine dependence. This association, robust to control for other childhood adversities, suggests that maltreatment (rather than a generally difficult childhood) affects the course of dependence.

Original language	American English
Journal	Addiction
Volume	109
DOIs	https://doi.org/10.1111/add.12477
State	Published - May 2014

Keywords

abuse
alcohol
child
chronic
course
dependence
maltreatment
neglect
nictoine
persistence

Disciplines

Psychology

Access to Document

10.1111/add.12477

Cite this

@article{b37e908a171b4b01adfbab9496112f89,

title = "The risk for persistent adult alcohol and nicotine dependence: the role of childhood maltreatment",

abstract = " Background and aims: Alcohol and nicotine dependence are associated with considerable morbidity and mortality, especially when cases are persistent. The risk for alcohol and nicotine dependence is increased by childhood maltreatment. However, the influence of childhood maltreatment on dependence course is unknown, and is evaluated in the current study. Design: Physical, sexual and emotional abuse, and physical and emotional neglect, were evaluated as predictors of persistent alcohol and nicotine dependence over 3 years of follow-up, with and without control for other childhood adversities. Setting: National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Participants: NESARC participants completing baseline and follow-up who met criteria at baseline for past-year alcohol dependence (n = 1172) and nicotine dependence (n = 4017). Measurements: Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS) measures of alcohol/nicotine dependence, childhood maltreatment and other adverse childhood experiences (e.g. parental divorce). Findings: Controlling for demographics only, physical, sexual and emotional abuse and physical neglect predicted 3-year persistence of alcohol dependence [adjusted odds ratio (AOR) = 1.50-2.99; 95\% CI = 1.04-4.68] and nicotine dependence (AOR = 1.37-1.74; 95\% CI = 1.13-2.11). With other childhood adversities also controlled, maltreatment types remained predictive for alcohol persistence (AOR = 1.53-3.02; 95\% CI = 1.07-4.71) and nicotine persistence (AOR = 1.35-1.72; 95\% CI = 1.11-2.09). Further, a greater number of maltreatment types incrementally influenced persistence risk (AOR = 1.19-1.36; 95\% CI = 1.11-1.56). Conclusions: A history of childhood maltreatment predicts persistent adult alcohol and nicotine dependence. This association, robust to control for other childhood adversities, suggests that maltreatment (rather than a generally difficult childhood) affects the course of dependence.",

keywords = "abuse, alcohol, child, chronic, course, dependence, maltreatment, neglect, nictoine, persistence",

author = "Elliott, \{Jennifer C\} and Malka Stohl and Wall, \{Melanie M.\} and Keyes, \{Katherine M\} and Goodwin, \{Renee D\} and Skodol, \{Andrew E.\} and Krueger, \{Robert F\} and Grant, \{Bridget F.\} and Hasin, \{Deborah S\}",

note = "Background and aims: Alcohol and nicotine dependence are associated with considerable morbidity and mortality, especially when cases are persistent. The risk for alcohol and nicotine dependence is increased by childhood maltreatment. However, the influence of childhood maltreatment on dependence course is unknown, and is evaluated in the current study.",

year = "2014",

month = may,

doi = "10.1111/add.12477",

language = "American English",

volume = "109",

journal = "Addiction",

issn = " 1360-0443",

publisher = "Wiley Blackwell",

}

TY - JOUR

T1 - The risk for persistent adult alcohol and nicotine dependence: the role of childhood maltreatment

AU - Elliott, Jennifer C

AU - Stohl, Malka

AU - Wall, Melanie M.

AU - Keyes, Katherine M

AU - Goodwin, Renee D

AU - Skodol, Andrew E.

AU - Krueger, Robert F

AU - Grant, Bridget F.

AU - Hasin, Deborah S

N1 - Background and aims: Alcohol and nicotine dependence are associated with considerable morbidity and mortality, especially when cases are persistent. The risk for alcohol and nicotine dependence is increased by childhood maltreatment. However, the influence of childhood maltreatment on dependence course is unknown, and is evaluated in the current study.

PY - 2014/5

Y1 - 2014/5

N2 - Background and aims: Alcohol and nicotine dependence are associated with considerable morbidity and mortality, especially when cases are persistent. The risk for alcohol and nicotine dependence is increased by childhood maltreatment. However, the influence of childhood maltreatment on dependence course is unknown, and is evaluated in the current study. Design: Physical, sexual and emotional abuse, and physical and emotional neglect, were evaluated as predictors of persistent alcohol and nicotine dependence over 3 years of follow-up, with and without control for other childhood adversities. Setting: National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Participants: NESARC participants completing baseline and follow-up who met criteria at baseline for past-year alcohol dependence (n = 1172) and nicotine dependence (n = 4017). Measurements: Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS) measures of alcohol/nicotine dependence, childhood maltreatment and other adverse childhood experiences (e.g. parental divorce). Findings: Controlling for demographics only, physical, sexual and emotional abuse and physical neglect predicted 3-year persistence of alcohol dependence [adjusted odds ratio (AOR) = 1.50-2.99; 95% CI = 1.04-4.68] and nicotine dependence (AOR = 1.37-1.74; 95% CI = 1.13-2.11). With other childhood adversities also controlled, maltreatment types remained predictive for alcohol persistence (AOR = 1.53-3.02; 95% CI = 1.07-4.71) and nicotine persistence (AOR = 1.35-1.72; 95% CI = 1.11-2.09). Further, a greater number of maltreatment types incrementally influenced persistence risk (AOR = 1.19-1.36; 95% CI = 1.11-1.56). Conclusions: A history of childhood maltreatment predicts persistent adult alcohol and nicotine dependence. This association, robust to control for other childhood adversities, suggests that maltreatment (rather than a generally difficult childhood) affects the course of dependence.

AB - Background and aims: Alcohol and nicotine dependence are associated with considerable morbidity and mortality, especially when cases are persistent. The risk for alcohol and nicotine dependence is increased by childhood maltreatment. However, the influence of childhood maltreatment on dependence course is unknown, and is evaluated in the current study. Design: Physical, sexual and emotional abuse, and physical and emotional neglect, were evaluated as predictors of persistent alcohol and nicotine dependence over 3 years of follow-up, with and without control for other childhood adversities. Setting: National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Participants: NESARC participants completing baseline and follow-up who met criteria at baseline for past-year alcohol dependence (n = 1172) and nicotine dependence (n = 4017). Measurements: Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS) measures of alcohol/nicotine dependence, childhood maltreatment and other adverse childhood experiences (e.g. parental divorce). Findings: Controlling for demographics only, physical, sexual and emotional abuse and physical neglect predicted 3-year persistence of alcohol dependence [adjusted odds ratio (AOR) = 1.50-2.99; 95% CI = 1.04-4.68] and nicotine dependence (AOR = 1.37-1.74; 95% CI = 1.13-2.11). With other childhood adversities also controlled, maltreatment types remained predictive for alcohol persistence (AOR = 1.53-3.02; 95% CI = 1.07-4.71) and nicotine persistence (AOR = 1.35-1.72; 95% CI = 1.11-2.09). Further, a greater number of maltreatment types incrementally influenced persistence risk (AOR = 1.19-1.36; 95% CI = 1.11-1.56). Conclusions: A history of childhood maltreatment predicts persistent adult alcohol and nicotine dependence. This association, robust to control for other childhood adversities, suggests that maltreatment (rather than a generally difficult childhood) affects the course of dependence.

KW - abuse

KW - alcohol

KW - child

KW - chronic

KW - course

KW - dependence

KW - maltreatment

KW - neglect

KW - nictoine

KW - persistence

U2 - 10.1111/add.12477

DO - 10.1111/add.12477

M3 - Article

SN - 1360-0443

VL - 109

JO - Addiction

JF - Addiction

ER -