Mouse chromosome fragility

Maureen M Sanz; Edmund C. Jenkins; W. Ted Brown; Muriel T. Davisson; Monica J. Kevin; Thomas H. Roderick; Wayne P. Silverman; Henryk M. Wisniewski; John M. Opitz; James F. Reynolds

doi:10.1002/ajmg.1320230141

Mouse chromosome fragility

Maureen M Sanz
, Edmund C. Jenkins
, W. Ted Brown
, Muriel T. Davisson
, Monica J. Kevin
, Thomas H. Roderick
, Wayne P. Silverman
, Henryk M. Wisniewski
, John M. Opitz
, James F. Reynolds

Biology, Chemistry, Environmental Studies

City University of New York
Cornell University
Kennedy Krieger Institute
University of Wisconsin-Madison
Oregon Health & Science University

Producción científica: Article › revisión exhaustiva

Resumen

<div class="line" id="line-5"> <span style='color: rgb(28, 29, 30); font-family: "Open Sans", sans-serif, icomoon; font-size: 16px;'> When cultures of fibroblast&hyphen;like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5&hyphen;fluoro&hyphen;deoxyuridine (FUdR), non&hyphen;random strain&hyphen;specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain&hyphen;specific fragile sites were identified in strain RBC/Dn at G&hyphen;band 15A2, and at G&hyphen;band 19B in strain AEJ/GnRk. Constitutive fragile sites at G&hyphen;bands 12A2 and 18A2 were identified in both strains. A strain&hyphen;specific marker at G&hyphen;band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies. </span></div>

Idioma original	American English
Páginas (desde-hasta)	491
Número de páginas	509
Publicación	American Journal of Medical Genetics
Volumen	23
N.º	1-2
DOI	https://doi.org/10.1002/ajmg.1320230141
Estado	Published - ene 1986

Disciplines

Life Sciences

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10.1002/ajmg.1320230141

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@article{ca6d5a285a894b1c898e04a5d5f0ce90,

title = "Mouse chromosome fragility",

abstract = " When cultures of fibroblast\&hyphen;like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5\&hyphen;fluoro\&hyphen;deoxyuridine (FUdR), non\&hyphen;random strain\&hyphen;specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain\&hyphen;specific fragile sites were identified in strain RBC/Dn at G\&hyphen;band 15A2, and at G\&hyphen;band 19B in strain AEJ/GnRk. Constitutive fragile sites at G\&hyphen;bands 12A2 and 18A2 were identified in both strains. A strain\&hyphen;specific marker at G\&hyphen;band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies. ",

author = "Sanz, \{Maureen M\} and Jenkins, \{Edmund C.\} and Brown, \{W. Ted\} and Davisson, \{Muriel T.\} and Kevin, \{Monica J.\} and Roderick, \{Thomas H.\} and Silverman, \{Wayne P.\} and Wisniewski, \{Henryk M.\} and Opitz, \{John M.\} and Reynolds, \{James F.\}",

note = "Enter your email address below. If your address has been previously registered, you will receive an email with instructions on how to reset your password. If you don't receive an email, you should register as a new user",

year = "1986",

month = jan,

doi = "10.1002/ajmg.1320230141",

language = "American English",

volume = "23",

pages = "491",

journal = "American Journal of Medical Genetics",

issn = "1552-4833",

publisher = "Wiley Blackwell",

number = "1-2",

}

TY - JOUR

T1 - Mouse chromosome fragility

AU - Sanz, Maureen M

AU - Jenkins, Edmund C.

AU - Brown, W. Ted

AU - Davisson, Muriel T.

AU - Kevin, Monica J.

AU - Roderick, Thomas H.

AU - Silverman, Wayne P.

AU - Wisniewski, Henryk M.

AU - Opitz, John M.

AU - Reynolds, James F.

N1 - Enter your email address below. If your address has been previously registered, you will receive an email with instructions on how to reset your password. If you don't receive an email, you should register as a new user

PY - 1986/1

Y1 - 1986/1

N2 - When cultures of fibroblast&hyphen;like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5&hyphen;fluoro&hyphen;deoxyuridine (FUdR), non&hyphen;random strain&hyphen;specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain&hyphen;specific fragile sites were identified in strain RBC/Dn at G&hyphen;band 15A2, and at G&hyphen;band 19B in strain AEJ/GnRk. Constitutive fragile sites at G&hyphen;bands 12A2 and 18A2 were identified in both strains. A strain&hyphen;specific marker at G&hyphen;band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

AB - When cultures of fibroblast&hyphen;like cells from inbred mouse strains RBC/Dn and AEJ/GnRk were exposed to 5&hyphen;fluoro&hyphen;deoxyuridine (FUdR), non&hyphen;random strain&hyphen;specific distributions of chromosome gaps, breaks and exchanges were observed. Throughout the genomes there appeared to be specific sites at which lesions occurred preferentially. Two strain&hyphen;specific fragile sites were identified in strain RBC/Dn at G&hyphen;band 15A2, and at G&hyphen;band 19B in strain AEJ/GnRk. Constitutive fragile sites at G&hyphen;bands 12A2 and 18A2 were identified in both strains. A strain&hyphen;specific marker at G&hyphen;band 9B was found in strain AEJ/GnRk. The fragile sites reported here provide an animal model for the study of chromosome fragility as well as polymorphic markers for linkage studies.

U2 - 10.1002/ajmg.1320230141

DO - 10.1002/ajmg.1320230141

M3 - Article

SN - 1552-4833

VL - 23

SP - 491

JO - American Journal of Medical Genetics

JF - American Journal of Medical Genetics

IS - 1-2

ER -